Methyl acetate nwere ísì ụtọ, ụtọ mkpụrụ na ekpomeekpo dị ntakịrị.Enwere ike ịkwadebe ya site na esi acetic acid na methanol n'ihu ihe na-eme ka acid;ma ọ bụ site na kpo oku methanol na ngafe carbon monoxide n'okpuru nrụgide na ọnụnọ nke ihe mkpali (phosphoric acid, cobalt salts).
Methyl acetate na-apụta n'ụzọ nkịtị na obere mkpokọta dị na mint, ero, mkpụrụ vaịn, banana, kọfị (Furia na Bellanca, 1975) na bụ ihe na-agbanwe agbanwe nke nectarines (Takeoka et al., 1988).Ọ dịkwa na ụfọdụ mmanya na-egbu egbu (Shimoda et al., 1993).A na-emepụta ya na ụlọ ọrụ site na carbonylation nke methanol dị ka ihe sitere na mmepụta acetic acid ma ọ bụ site na esterification nke acetic acid na methanol n'ihu acid siri ike dị ka sulfuric acid.